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Correlation of Neuropsychological and MRI Findings in Chronic/Progressive Multiple Sclerosis Neurol 38:1826-1829, Franklin,G.M.,et al, 1988 See this aricle in Pubmed Article Abstract Sixty patients with chronic/progressive MS received a newly assembled neuropsychological screening battery(NSB)and a brain MRI.A neuroradiologist blinded to NSB findings quantified cerebral lesions on MRI.We developed weighted brain area lesion scores according to number and size of cerebral lesions.Patients who were impaired on NSB testing had a significantly higher mean bihemispheric lesion score(X=26.1)then those who were unimpaired(X=17.4);this MRI lesion rating score correlated significantly with the cognitive summary score of the NSB(r=0.35,p<0.01). However,we did not find a significant correlation between the Kurtzke Expanded Disability Status Scale and any MRI or NSB summary measures. Compared with the Mini-Mental State Exam(MMSE),the NSB cognitive summary score yielded a prevalence estimate for cognitive impairment that is more consistent with previous findings in chronic/progressive MS.The NSB is a useful screening test for cognitive dysfunction in chronic/progressive MS because of its relationship to cerebral lesions on MRI and its greater sensitivity than the frequently used MMSE.

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(click to filter results - removes previous filter) MRI MRI,abnormal multiple sclerosis multiple sclerosis,chronic progressive psychological testing

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